ABSTRACT
It is not surprising that several studies have examined the possible use of ACE inhibitors in angina. One might expect a beneficial effect as a result of improved LV and endothelial function. In fact, results have been uniformly disappointing, with at best a very modest response and generally no response at all.26,27
An interesting ancillary effect of the drugs has emerged, however, in patients treated with long-acting nitrates. Concomitant treatment with ACE inhibitors retards the development of nitrate tolerance, apparently maintaining the cyclic GMP response to nitrates in vascular smooth muscle.28,29 The mechanism is not known.
