ABSTRACT
This is the most widely used class of diuretics
in the management of heart failure. Loop
diuretics are actively excreted into the tubular
lumen, where they cause a potent diuresis by
blocking active chloride transport from the
thick ascending limb of the loop of Henle
Sites of diuretic action
LOOP V2 antagonist
Ksparing
Na
K
Aldosterone
NaCl thiazide
Na
Cl
H2O ADH
H2O
(Figure 5.1 ), which normally cotransports
sodium and water out of the renal tubule.
