Enzymes acting on DNA breaks and its relevance in nucleic acid-based therapy

INTRODUCTION In nucleic acid-based therapy, oligonucleic acids are used as a drug to treat genetic and acquired diseases. The stability or half-lives of such oligonucleic acids in cells are likely to be affected by cellular enzymes. One group of enzymes, which would interact with the therapeutic oligonucleic acids, are those involved in the process of DNA repair.