ABSTRACT
The increasing resistance of bacteria towards all current classes of antibiotics is now a serious health problem in both developed and developing countries. Antibiotic Development and Resistance presents 15 chapters that explore the medical issues raised by this development and review the relevant literature. The book begins by reviewing the global
TABLE OF CONTENTS
chapter 1|22 pages
A Global Perspective on Bacterial Infections, Antibiotic Usage, and the Antibiotic Resistance Problem
Lars G.Burman and Barbro Olsson-Liljequist
chapter 2|14 pages
Target Mutations Mediating Antibiotic Resistance
Diarmaid Hughes and Dan I.Andersson
chapter 3|16 pages
Evolution of Multiple Antibiotic Resistance by Acquisition of New Genes
Ruth M.Hall and Sally R.Partridge
chapter 4|12 pages
Adaptive Resistance to Antibiotics
Yan-Qiong Xiong, Arnold S.Bayer and Gilles Potel
chapter 5|26 pages
Efflux Mechanisms: Molecular and Clinical Aspects
Olga Lomovskaya, Mark S.Warren and Ving Lee
chapter 7|10 pages
Mutator Bacteria and Resistance Development
Thomas A.Cebula, Dan D.Levy and J.Eugene LeClerc
chapter 9|18 pages
Possible Impact on Antibiotic Resistance in Human Pathogens Due to Agricultural Use of Antibiotics
Abigail A.Salyers and Patty McManus
chapter 10|8 pages
Fitness and Virulence of Antibiotic Resistant Bacteria
Dan I.Andersson, Johanna Björkman and Diarmaid Hughes
chapter 11|18 pages
Evolutionary Consequences and Costs of Plasmid-Borne Resistance to Antibiotics
Santiago F.Elena
chapter 12|16 pages
Structural Insights into Antibiotic-Target Interactions
Elspeth Gordon, Nicolas Mouz, Thierry Vernet and Otto Dideberg
chapter 13|12 pages
New Targets and Strategies for Identification of Novel Classes of Antibiotics
Molly B.Schmid
chapter 15|28 pages
Molecular Genetic and Combinatorial Biology Approaches to Produce Novel Antibiotics
Richard H.Baltz
