chapter  17
52 Pages

Anticancer agents

The DNA molecule is essential for the growth of all living cells and so far it has been the main target for anticancer drug action. Some of these drugs act directly on the DNA molecule, either by drug-induced DNA damage or by some kind of alteration of DNA (Section 17.1.1), whereas other drugs prevent nucleic acid synthesis by inhibiting one or more of the enzymes involved in the DNA synthesis, or by disturbing the DNA function by incorporation of ‘wrong pieces’ into the DNA molecule (Section 17.1.2).