ABSTRACT
Description: Metalyse (TNKase in the U.S.) is a recombinant 525-amino acid glycoprotein derived from the human tissue plasminogen activator (tPA). It differs from the natural molecule in the residues at position 103 (a threonine residue replaced by an asparagine), 117 (asparagine replaced by glutamine), 296 (lysine replaced by alanine), 297 (histidine replaced by alanine), and 298 and 299 (arginines replaced by alanines). It is produced by recombinant DNA technology in Chinese hamster ovary (CHO) cells. The final product is presented in a lyophilized form to be reconstituted using the provided solvent-filled syringe before intravenous administration.
