ABSTRACT
I. INTRODUCTION Nonsteroidal anti-inflammatory drugs (NSAIDs) as a class are an important cause of druginduced toxic injury to several organ systems, including well-known injury to the gastrointestinal tract and kidneys. While perhaps less well appreciated, NSAIDs are a leading cause of drug-induced hepatotoxicity. For instance, in Denmark, NSAIDs accounted for approximately 9% (97 of 1100) of all drug-related liver injury reports between 1978 and 1987 (1) and they continue to be reported at a rate that often exceeds other drug classes (2).
