ABSTRACT
I. BIOLOGICAL BACKGROUND A. Angiogenesis The term angiogenesis was first coined by Judah Folkman (Folkman, 1971) to identify the process leading to the formation of new blood vessels from the existing tissue of the vascular bed. Before Folkman’s studies, several pathologists had noted that tumor tissues are hypervascularized, but it was believed that this was a passive phenomenon related to hyperemia and vessels congestion.
