ABSTRACT
Staphylokinase (Sak), a bacterial profibrinolytic agent, readily available by recombinant DNA
technology, is a 136-amino-acid, single-chained polypeptide, with a unique structure and
mechanism of action and of fibrin specificity. Preclinical investigations disclosed attractive
characteristics, including high-thrombolytic potency, also toward platelet-rich thrombi and fibrin
specificity in human plasma.
