ABSTRACT
Proteoglycans appear to be key matrix components in scarring after an injury (see Chapter 1), although their roles have not been well defined. Their role in skin and other tissues in relation to structure (1) can be divided into two main types of function, consisting of relatively nonspecific charge and size effects of the glycosaminoglycan components, and specific interactions directly due to the microstructure of the glycosaminoglycans and/or the structure of the core proteins. Usually, but not always, the glycosaminoglycans serve as the functional ‘‘business ends’’ while the core proteins serve to direct transport and channeling for biosynthesis, placement, and maintenance in appropriate locations.
