ABSTRACT
Drug insolubility is one of the most intractable problems in new drug development and in reformulation of existing medications. This chapter describes a novel approach, Insoluble Drug Delivery (IDD) technology, which has successfully addressed the problem of water-insoluble drug delivery. Without intending a comprehensive review of the latter, this chapter briefly compares the attributes of the IDD approach and other formulation technologies for water-insoluble drugs. Example formulations employing IDD technology are discussed, particularly with respect to their ability to improve oral bioavailability.
