ABSTRACT
This chapter describes the intraorally disintegrating or dissolving tablets OraSolv, and the second-generation platform, DuraSolv, developed and manufactured by CIMA LABS Inc. The taste of the active ingredient in these products is masked by the use of an appropriate coating over the drug particles in conjunction with effective flavoring agents and an artificial sweetener. They are designed to facilitate the administration of medication to patients who experience difficulty in swallowing (dysphagia) and for the convenience of all patients since the products may be administered at any time, without the need for water or other liquid to aid swallowing. Additionally, these technologies help pharmaceutical companies to extend the life cycle of their products and to differentiate them in the marketplace. The technologies for the formulation, production, and packaging of the tablets are covered by several patents as indicated below.
