ABSTRACT
Electrotransport technology (referred to as E-TRANS technology at ALZA Corporation, Mountain View, CA) uses an electric potential to provide noninvasive delivery of therapeutic substances across intact skin for local and systemic applications. An electrotransport drug delivery system typically consists of a power supply connected to a pair of electrodes in contact with ionically conductive reservoirs that, in turn, are in contact with the skin. Since the rate of drug delivery is proportional to the applied electrical current, electrotransport systems have the potential to provide precise dosing as well as patterned and on-demand delivery.
