ABSTRACT

At the beginning of the 1990s, solid lipid nanoparticles (SLN) manufactured from polymers and macromolecules were developed as an alternative carrier system to emulsions, liposomes, and nanoparticles. The matrix of SLN comprises solid lipids, and in general, they are produced by high-pressure homogenization [1-3]. An alternative production method is the microemulsion technique [4]. The features of SLN can be summarized in one sentence: they combine the advantages of traditional dosage forms such as emulsions, but simultaneously avoid some of the pronounced disadvantages associated with such systems.