ABSTRACT
This chapter describes the development and unique features of the Atrigel drug delivery system, and its application for the delivery of various drug products. The Atrigel system is a proprietary delivery system that can be used for both parenteral and site-specific drug delivery. It consists of biodegradable polymers dissolved in a biocompatible carrier. When the liquid polymer system is placed in the body using standard needles and syringes, it solidifies upon contact with aqueous body fluids to form a solid implant. If a drug is incorporated into the polymer solution, it becomes entrapped within the polymer matrix as it solidifies. The drug is then released over time as the polymer biodegrades. The technology for the Atrigel system is protected by 33 patents in the United States and 35 patents in the rest of the world. These patents cover the basic technology as well as process improvements.
