ABSTRACT
There is increasing evidence that some H1-receptor antagonists possess a variety of activities not explained by H1-antagonism. These antiallergic, anti-inflammatory activities can be studied in vitro, in vivo, and ex vivo. In vivo (in humans) allergen challenge of the skin, nose, lung, and eye has been useful in studying the role of anti-inflammatory properties. The clinical significance of antiallergic, anti-inflammatory effects beyond H1-receptor blockade is currently an important area of investigation.
