ABSTRACT
Figure 1 Histology of sCJD (A, B) and vCJD (C, D). (A) Hematoxylin-eosin (HE) stain of sCJD showing spongiform change (2-10 m vacuoles) and confluent vacuoles (10-50 m) as well as neuronal loss. (B) Immunohistochemical demonstration of PrPres with synaptic pattern of deposition in the granular and molecular layers of the cerebellum. (C) HE stain of vCJD showing a fluoride plaque surrounded by spongiform change. (D) Immunohistochemical demonstration of PrPres in the cerebellum. (A,B: courtesey of Dr. Hans A. Kretzschmar, Institute of Neuropathology, Munich, Germany; C,D: Courtesey of Dr. James Ironside, CJD Surveillance Unit, Edinburgh, Scotland.)
Scheinker disease (GSS), in a 25-year-old female patient presenting with ataxia, slurred speech, and mental changes.
