ABSTRACT
This concept goes back to 1946 when Spiegal and Wycis treated a patient with Huntington’s chorea by injecting alcohol into the globus pallidus and medial thalamus, using their own stereotactic reference system [1]. This provided short-term benefit but enabled the technique to be applied to other functional conditions, such as intractable pain, anxiety, and aggressive disorders, as well as movement disorders.
