ABSTRACT
Factorial designs are used in experiments where the effects of different factors, or conditions, on experimental results are to be elucidated. Some practical examples where factorial designs are optimal are experiments to determine the effect of pressure and lubricant on the hardness of a tablet formulation, to determine the effect of disintegrant and lubricant concentration on tablet dissolution, or to determine the efficacy of a combination of two active ingredients in an over-the-counter cough preparation. Factorial designs are the designs of choice for simultaneous determination of the effects of several factors and their interactions. This chapter introduces some elementary concepts of the design and analysis of factorial designs.
