Lung Deposition Simulation

Inhaled pharmaceutical aerosols cannot act unless they deposit in the respiratory

tract. However, the amount and location of such deposition is strongly affected by

several factors, including aerosol properties, breath pattern, and lung geometry.

Since some control over aerosol properties and breath pattern is possible when

designing an inhaled aerosol formulation, access to tools that permit parametric

exploration of lung deposition is useful in order to optimize these parameters

and guide preclinical development. It is for this reason that methods allowing

simulation of deposition in the lung have become increasingly common in the

respiratory drug delivery arena.