ABSTRACT
Somatostatin receptors (SSR) are expressed by the majority of neuroendocrine tumors, including pancreatic endocrine tumors. Several subtypes of SSR exist. SSR subtype 2 predominance has been found in 80% of pancreatic endocrine tumors (1). Octreotide, a somatostatin analogue used to treat selected symptomatic patients with neuroendocrine tumors, binds to SSR subtype 2 and subtype 5. Indium-111 (In-111)–labeled octreotide is the most commonly used radiotracer for imaging of pancreatic endocrine tumors. Readers interested in details of the imaging protocol are referred to guidelines published by the Society of Nuclear Medicine (2).
