ABSTRACT

Adaption of fungal and other natural product extracts, which contain chromophores and fluorophores, to modern screening techniques is a continuing challenge. Sample prepa-

ration, assay validation, detection of activity, confirmation of activity, and assay support for isolating the active components are all crucial to the success of a program. In this chapter, we discuss a variety of these assays and related issues and also suggest some techniques and approaches that can be successfully employed.