ABSTRACT
To obtain a prolonged action dosage form of ketoprofen, three different techniques for delaying drug release from hydrophilic matrices of hydroxypropylmethylcellulose were evaluated. They were incorporation of glyceryl monostearate, as a release controller, partial coating with an impermeable covering of cellulose acetate phthalate, and pan-spray coating with a mixture of insoluble (Eudragit) and soluble (PEG 400) polymers. The in vitro release profiles of each formulation were studies using the USP basket method. Pan-spray coating with the Eudragit-PEG mixture was found to be the best technique, enabling the desired release profile to be obtained through variation of the coating thickness.
