ABSTRACT
Biodegradable polymers, such as poly(lactic acid) and poly(caprolactone), were investigated as binders in the formulation of matrix tablets for controlled release. Polymers of different stereo configuration and molecular weights were incorporated into tablet formulations containing the model drug theophylline in combination with excipients such as microcrystalline cellulose. It was shown that thermal treatment of these tablets above the glass transition temperature of the polymer accelerated, retarded or had an insignificant effect on the dissolution release rate of theophylline from the compact, as compared with the non-thermally treated tablets.
