A comparison of dissolution properties from matrix tablets prepared from microcapsules and mixtures containing phenobarbitone and poly(DL-lactic acid)

doi:10.3109/9780203979099-21

Chapter

A comparison of dissolution properties from matrix tablets prepared from microcapsules and mixtures containing phenobarbitone and poly(DL-lactic acid)

ABSTRACT

Microcapsules for use in the preparation of sustained release formulations have been under investigation for a number of years without any great success. There is an initially rapid release, due to the porosity of the wall coupled with the effect of wall saturation, which builds up during long storage. Compression has provided formulations with better sustained release characteristics.