ABSTRACT
Objective: Meta analysis was used to investigate the effect of antibiotic prophylaxis on tension free inguinal herniorrhaphy which was related to the surgical site infections. Methods: Pertinent literature were retrieved by keywords/subheadings of MeSH in databases. According to the inclusion and exclusion criteria, the literature were screened related to the original, independent, and randomized clinical trials. Then, evaluating those literature using Jadad scoring criteria and excluding those evaluating results less then 3, 6 English literature were met the criteria and ultimately obtained, in which there were 2379 cases. And then, the relevant data was analyzed by using Meta statistical method. Results: In the cases of antibiotic prophylaxis on tension free inguinal herniorrhaphy, the results showed no statistical significance (P = 0.39, OR = 0.83, 95% CI of 0.55 ~ 1.27; P = 0.43, OR = 0.84, 95% CI of 0.54 ~ 1.30; P = 0.71, OR = 0.78, 95% CI of 0.21 ~ 2.93) for the surgical site infection overall incidence, the superficialincision surgical site infection incidence, and the deepincision surgical site infection incidence within the control and experimental groups. Therefore, the result suggested that antibiotic prophylaxis on tension free inguinal herniorrhaphy may not produces a preventive effect for surgical site infection overall incidence, superficialincision surgical site infection incidence, and deepincision surgical site infection incidence. Conclusions: Antibiotic prophylaxis on tension free inguinal herniorrhaphy can not reduce surgical site infection overall incidence, superficialincision surgical site infection incidence, deepincision surgical site infection incidence and incidence of complications, it was recommended that antibiotic should be carefully used in the clinic.
