ABSTRACT
Feng Zhao, Chuan Wang, Zheng Wei, Zhi-hang Liu & Bao-qing Xu Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
Di-ya Yang, Ke-gao Liu & Ning-li Wang Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing, China
Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
ABSTRACT: Primary Open-Angle Glaucoma (POAG) is the most common form of glaucoma and its etiology remains unknown. Recent research suggests that abnormal rising of Trans-lamina Cribrosa Pressure Dierence (TCPD) caused by decrease of cerebrospinal fluid (CSF) pressure may be the pathogenesis of POAG. However, the TCPD (intraocular pressure minus CSF pressure of optic nerve subarachnoid space) had not been directly measured, but was calculated clinically as dierence of intraocular pressure (IOP) minus lumbar CSF pressure instead. In this paper, an IOP and CSF pressure-measuring device was developed and validated. Accuracy was obtained through a water-column pressure-measuring experiment with the maximum absolute error of 0.4 mmH2O. Then the TCPD of three adult New Zealand White rabbits was measured (4.19 ± 0.52 mmHg). This method might help to research the relationship between the increase of TCPD and primary open-angle glaucoma.
