ABSTRACT
Cocaine Synonyms: badrock, bazooka, benzoylethylecgonine, benzoylmethylecgonine, bernice,
bernies, beta-cocain, blast, blizzard, blow, bouncing powder, bump, burese, “C”, carrie, coc, cabello, candy, carrie, caviar, cecil, charlie, chicken scratch, cholly, coca, cocain, cocaina, cocaine free base, cocaine, l-cocaine-M, cocktail, coke, cola, corine, d-pseudococaine, dama blanca, delcaine, depsococaine, dextrocaine, dust, ecgonine, methyl ester, benzoate, eritroxilina, erytroxylin, flake, flex, florida snow, foo foo, freeze, g-rock, girl, gold dust, goofball, green gold, happy dust, happy powder, happy trails, heaven, hell, isocaine, isococain, isococaine, jam, kibbles ‘n’ bits, kokain, kokan, kokayeen, l-cocain, l-cocaine, lady, leaf, line, methyl benzoylecgonine, moonrocks, neurocaine, none, pimp’s drug, prime time, rock, sleighride, snort, star dust, star-spangled powder sugar, sweet stuff, toke, toot, trails, white girl or lady, yeyo, zip
Systematic name: methyl-3-benzoyloxy-8-methyl-8 azabicyclo[3.2.1]octane-4-carboxylate Formula: C17H21NO4 Molecular weight: 303.353 daltons Cmax: (20 mg IV, n = 7) 124 ± 11.7, (40 mg IV, n = 7) 382.79 ± 84 ng/mL (Winhusen
et al., 2006); (15 mg, n = 5) 191 ± 67.6, (40 mg, n = 5) 470.4 ± 70.8 (Cone et al., 1988) Elimination rate constant: (40 mg IV, n = 7) 0.13, (40 mg IV, n = 7) 0.12 (Winhusen
et al., 2006) Elimination half-life (min): (40 mg IV, n = 7) 58.5 ± 8.4, (40 mg IV, n = 7) 60.6 ± 5.9
(Winhusen et al., 2006), (15 mg, n = 5) = 32.5 ± 5, (40 mg, n = 5) = 37.3 ± 1.8 AUC (ng/mL/min): (20 mg IV, n = 7) 11,461 ± 1326, (40 mg IV, n = 7) 28,510 ± 2304
(Winhusen et al., 2006), (40 mg, n = 5) = 21,838 ± 2970 (Cone et al., 1988) Volume of distributionss (L/kg): (20 mg IV, n = 7), (40 mg IV, n = 7) 2.22 ± 0.121 ±
0.13, 0.020 ± 0.003 (Winhusen et al., 2006); (15 mg, n = 5) = 1.63 ± 0.324; (40 mg, n = 5) = 1.5 ± 0.27
Clearance (L/min/kg): 0.026 ± 0.003 (Winhusen et al., 2006), (n = 5, 15 mg), = 2359 ± 200 L/min/kg), = 2042 mg/L ± 312 (n = 5, 40 mg) (Winhusen et al., 2006)
Cocaine hydrochloride, stored in a tightly closed container at room temperature, will not decompose for at least five years. Solutions are stable for at least 21 days, provided the temperature is below 24°C and the pH is below 4.0. At pH levels above 4.0 hydrolysis rapidly occurs (Muthadi and Al-Bader, 1986).
