ABSTRACT
High-throughput screening is a well-established method that dominates the discovery of compounds that can become clinical candidates. A critical factor for its success has been the assembly of an adequate chemical collection, geared to produce multiple high-quality hits with efcient use of resources (Bakken et al., 2012). Library design should not be viewed as an entirely creative process. The term design is used to convey the idea of purpose, planning, and intention in assembling a chemical collection for use. The design process will vary with the intended use of the collection, which may include not only commercially available or easy-to-synthesize compounds, but also virtual collections of structures.
