ABSTRACT
Polymeric nanoparticles (NPs) have the benefit of permitting the entrapment of bioactive molecules and defending them against hydrolytic and enzymatic degradation. Pharmaceutically, polymeric NPs are the most preferred NPs owing to their considerably versatile physiochemistry, hemocompatibility, biocompatibility, biodegradability, and ease of functionalization properties. Among various naturally occurring substances, the most abundantly used and ideal materials for polymeric NP synthesis are the polysaccharides. Synthetic polymeric NPs are basically synthesized chemically using various chemicals and physical and chemical methodologies. The solvent evaporation technique is one of the leading approaches developed to prepare polymeric NPs from a previously formed polymeric layer. The salting out technique is a modified version of the emulsification/solvent diffusion method employed for the preparation of polymeric NPs. Dialysis, one of the simplest methods, is relevant for the manufacture of very small polymeric NPs with uniform size distribution. The ideal nanoparticulate system should have a high drug-loading capacity, thereby reducing the drug quantity for the administration.
