ABSTRACT
Carbon monoxide (CO) has received a considerable amount of attention because of its potentially lethal consequences in relatively small doses, coupled with the fact that human senses cannot detect CO. Ideally, mathematical model should take into account not only the level of CO exposure, but also the subject’s physiological characteristics and level of activity. This chapter explores the various models that have emerged and describes in detail the most successful model to date. Although the examination of the studies was confined to CO uptake, the Coburn-Forster-Kane (CFK) model is equally suited to predict CO elimination. Indeed, R. F. Coburn et al. applied the model to demonstrate that CO elimination is enhanced with increased pressure of O2 breathed M. L. McCartney conducted an elegant sensitivity analysis of the CFK model that provides both further insight on the uptake of CO and a useful guide on how each variable affects the model prediction.
