ABSTRACT
This chapter provides the reader with a firm understanding of basic mechanisms of the biochemistry and physiology of hemostasis. Basic mechanisms of hemostasis and thrombosis have become highly complex with expansions of investigation and knowledge. Although many clinicians and pathologists are reluctant to learn the basic physiology of hemostasis, it cannot be overemphasized how important this seemingly insurmountable task is. The vasculature represents the most neglected area of hemostasis and only recently has interest and consequently knowledge and appreciation of the key role of the vascular component of hemostasis been recognized. The platelets represent an extremely important, although complex, component of hemostasis and can no longer be thought of as inert cellular “buds” that “float” in the circulation. Platelets contain most of the organelles found in other cells. The biological effects of the fibrinogen degradation products on the hemostasis are significant in pathophysiology.
