ABSTRACT
The synergism of hyperthermia and selective cancer tissue overacidification, which had been assumed intuitively in the first presentation of the Cancer Multistem Therapy (CMT) concept in 1965, was proved by in vitro experiments using Ehrlich ascites tumor cells in 1968. Whether malignant cells are destroyed directly by the concerted attack of optimized cancer tissue acidification and extreme hyperthermia during CMT or indirectly by irreversible vascular obstruction depends on the values of the two governing physical parameters, which are necessary for triggering hemostasis. In large cancerous tissue areas, these two killing mechanisms will often act side by side, all the more as the vascularization of many tumor types is quite different. The irreversible microcirculation inhibition provoked in tumors can be utilized to improve the efficiency of high-dose cancer chemotherapy. This proposal is quite different from the well-known combination of drugs plus heat. Since 1971 the oxygen multistep immunostimulation method has been an integral constituent in the CMT program.
