ABSTRACT
Clinically applied hyperthermotherapy can be divided into local and total-body hyperthermia (TBH). Local hyperthermia has been primarily used in the treatment of superficial and localized malignant tumors. Various approaches for TBH have been tested, e.g., the heating gas inhalation method accompanied by the molten paraffin method, the hyperthermic chamber method, the heat-blanket method, and the water-perfusion suit method. J. M. Bull et al. and H. Neumann et al. reported clinical investigations on TBH treatment using a microwave instrument and a water suit. However, they did not comment on the therapeutic effects of their methods. In total-body hyperthermochemotherapy (TBHC) treatment, complications may arise from the physiological response to high temperatures. In TBHC treatment, cancerous tissues as well as normal organs are heated to a nonphysiological level for a long time, raising concerns that damage to the normal organs may ensue.
