ABSTRACT
Human brain tissue presents a variety of challenges to those planning to extract and purify biologically active molecules. These issues include:
• the potential need to maintain close to physiological conditions, • the need to prevent degradative processes associated with cell damage, • the need to accommodate the solubility characteristics of the molecule of
interest, • brain tissue is soft and when thawed is especially yielding, • white matter containing the neuronal axons is highly enriched in lipid in
the form of myelin which poses a potential obstacle to extraction procedures.
