ABSTRACT
Immunohistochemistry utilises antibodies to localise specific antigens in tissue. While such techniques have been widely used in studies of the nervous system in non-human species, it has only been in recent years that they have seen more extensive utilisation in investigations using human tissue. Immunohistochemistry can reveal the presence of a diverse range of markers. Thus, antibodies can be used to localise a broad range of nervous system components including neurotransmitters, neurotransmitter-related enzymes, receptor and channel subunits, cytoskeletal proteins, protein kinases, protein phosphatases, proteases, second-messenger molecules, membrane-associated proteins, calcium binding proteins, inflammatory markers and non-neuronal cell antigens.
