ABSTRACT
Pseudorabies is a natural disease of some domestic and wild animals. The porcine herpesvirus virion contains core, capsid, and envelope proteins. Since the envelope contains significant lipids, porcine herpesviruses are sensitive to lipid solvents. J. H. Subak-Sharpe et al. analyzed the pattern of nearest-neighbor base sequences for herpes simplex virus-1, porcine pseudorabies virus, and equine rhinopneumonitis viruses. The virus was first grown in tissue culture by E. Traub, who obtained growth in the Maitland-type tissue culture system of rabbit testis, and chick embryo. Infected cells have an eosinophilic homogenous Feulgen-positive intranuclear inclusion body. Various viral strains have been isolated and maintained in laboratories based on peculiar characteristics of the virion either in a natural setting or in artificial laboratory conditions. The epidemiology aspects of Porcine Herpesvirus 1 in swine is based on the fact that pigs are considered the natural host and reservoir of the virus. In lower dilutions most porcine immune sera must be treated with mercaptoethanol.
