ABSTRACT
Heterocyclic chemistry is constantly expanding and evolving as a result of the magnitude of research efforts directed towards this area. The majority of known molecules are heterocycles; they dominate the field of biochemistry, medicinal chemistry, and photographic sciences, and are of increasing importance in many other domains like polymers, adhesives and molecular engineering as well. G. Chouhan et al. reported the synthesis of L-proline supported on magnetic nanoparticles as a recoverable and recyclable ligand for N-arylation of heterocyclic compounds in the presence of cuprous iodide catalyst. Optimization studies have shown that both the N-heterocyclic carbene ligand and the Cu salt are essential for this transformation. Continuous modification of amine components wherein the haloatom is moved from their ortho position to ethynylbenzenes generates new heterocyclic products. The starting substrates bearing vinyl azide fragments reacted with terminal alkynes to produce triazole-fused heterocyclic products in the presence of cupric chloride and a base.
