ABSTRACT
Heterocycles with nitrogen-bridged frameworks are broadly present in a number of natural products and pharmaceuticals, possessing biological activities such as antitumor, antimalarial, antitubercular, antioxidant, antimicrobial, anticancer, anti-inflammatory, antiviral, and cytotoxicity through bacterial cell division and DNA alkylation activity, and have attracted the interest of many in the research fields of medicines and pharmaceuticals (Eftekhari-Sis, Zirak, and Akbari 2013, Eftekhari-Sis and Zirak 2014, Sutariya et al. 2015, Sharma and Kumar 2014). However, there are many reports on the construction of nitrogen-bridged heterocyclic compounds by multi-step synthesis in the literature; the development of new approaches to synthesis of these types of N-heterocycles with tolerance of different functional groups are of interest to synthetic and medicinal scientists.
