ABSTRACT
Asthma is the commonest chronic medical illness to complicate pregnancy, affecting up to 7% of women of childbearing age. Pregnancy provides an opportunity to diagnose asthma and to optimize the treatment of women already known to have asthma. Several biological drugs have been developed to treat allergic asthma including dupilumab and omalizumab. Increasing numbers of the children with cystic fibrosis (CF) are surviving into adulthood. Males are usually sterile, but although female fertility may be impaired in the malnourished or due to tenacious cervical mucus, it is usually normal. Some patients with CF exhibit reversibility in response to bronchodilators, and women should be reassured that inhaled and nebulized corticosteroids are safe for use in pregnancy. Inhaled dornase alfa (recombinant human deoxyribonuclease) hydrolyzes the DNA in the sputum, reducing the viscosity, is probably safe and should be continued in the pregnancy.
