ABSTRACT
This chapter describes the development of sedecamycin and the application of cyclodextrin to the fermentative production process. In the field of animal diseases, many antibiotics are used in Japan. Tetracycline-group antibiotics are widely used for growth promotion or prevention of infectious diseases. Macrolide antibiotics such as tylosin are used for increased weight gain in swine or improved feed efficiency in chickens. Polyether antibiotics such as salinomycin and monensin are used as anticoccidiostats for poultry and feed additives for cattle. Although many antibiotics have been developed and are widely used in animals, it is very important to check carefully for problems related to residual toxicity, environmental pollution, and cross-resistance of the antibiotics in addition to checking their effectiveness. Sedecamycin was obtained by the fermentation of a Streptomyces strain that was isolated from a soil sample collected in Nukata, Osaka, Japan, followed by enzymatic acetylation and extraction and purification.
