ABSTRACT
A parameter determined from the shape of a synthesis tree diagram for a synthesis plan that describes the degree of skewness of a triangle whose vertices are the target product node, the origin, and the node for the last reagent projected onto the ordinate axis. A synthesis plan that contains one branch made up of a consecutive sequence of reaction steps. A reaction step in a synthesis plan that does not result in the formation of a target bond that appears in the final target structure of the plan. A phrase often used in the organic synthesis literature to designate a synthesis plan to a known target molecule that has as a key feature a minimum number of reaction steps achieved compared with previously reported syntheses of that compound. A target bond forming reaction is a reaction step in a synthesis plan that involves forming a target bond that is found in the final product structure.
