ABSTRACT
25 An 8-year-old female spayed Dachshund presents for hair loss on the feet, licking between the toes, and generalized lethargy. On physical examination, a marked hyperkeratosis and fissuring of the footpads is noted (Figure 25.1). The skin lesions show pronounced peripheral reddening. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9780429401725/9d69b4ae-80d1-4f44-9dcb-659cda134065/content/fig25_1_C.jpg"/>
i. What is hepatocutaneous syndrome? What paraneoplastic endocrinopathy has been associated with this skin lesion in dogs?
ii. What is the cell of origin of this hormone?
iii. Dogs with this syndrome often show characteristic changes on ultrasound examination of the liver. What changes are typically seen?
iv. What therapeutic options are available?40
