ABSTRACT
Hypertension (HT) is the most common cardiovascular disease, and their management requires long-term treatment. The conventional dosage forms may result in poor patient compliance with due to greater frequency of drug administration. The poor aqueous solubility and poor metabolic stability of drugs are major limitations in successful drug delivery systems. There are several nanotechnology-based drug delivery system approaches have shown the potential to overcome the challenges associated with the administration routes. It addresses the formulation and application of substances and devices on the nanometer scale. There is an availability of a plethora of nanotechnology-based delivery system of therapeutically effective antihypertensive molecules, and arguably presents an opportunity to deliver through a different route. The present chapter focuses on various nanoformulations available for different administration routes for improving solubility, dissolution, and consequently bioavailability of antihypertensive drugs.
