ABSTRACT
This chapter presents mutually templated SM-Deoxyribonucleic acid (DNA) nanoarchitectures supported by canonical and noncanonical hydrogen bonding and ionic and metal interactions of nucleobases and their analogs. It discusses the concept of SM-DNA nanoarchitectonics and in particular, applications in the fields ranging from biology to materials science. The main advantages of SM-DNA nanoarchitectonics are the use of functional molecules and short single-stranded DNAs (ssDNA), which ensures built-in functional features and cost-effective technological platforms for practical applications. The short oligonucleotides have the capacity to induce programmed molecular organization within the templated assembly through well-defined molecular recognition. The chapter aims to construct SM-templated DNA nanoarchitectures and tools for numerous applications, including developing stimuli-responsive drug delivery systems. It shows that noncanonical hydrogen-bonding interactions have great potential for utilization in the development of novel templated DNA nanoarchitectures. The future directions for the field would also include use of templated assemblies of small molecules and DNA to program the nonbiological systems for controlling biological events.
