ABSTRACT
Evidence for brain abnormalities in people with Schizophrenia has been reviewed by Berman and Weinberger. As Berman and Weinberger point out, if there are differences in the brains of people with Schizophrenia and non-schizophrenics these differences are likely to be subtle and can be masked if there is a failure to control for such factors as the age and sex of subjects. Enlargement of the ventricals and widening of the cortical sulci in people with Schizophrenia was observed in studies using this method; however, the method was limited and invasive. When given certain tasks subjects with Schizophrenia show less blood flow to the frontal cortex than normal subjects. Lack of goal directed behaviour is very typical of people with Schizophrenia, as is a lack of hedonistic behaviour. The stronger arguments have led some researchers to focus on gonadal function, and the possible role of gonadotropic hormones in Schizophrenia.
