ABSTRACT

After the great expansion of genome-wide association studies, their scientific methodology and, notably, their data analysis has matured in recent years, and they are a keystone in large epidemiological studies. Newcomers to the field are confronted with a wealth of data, resources and methods. This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools and guides the reader through the use of publicly available data. Includes clear, readable programming codes for readers to reproduce and adapt to their own data.

  • Emphasises extracting biologically meaningful associations between traits of interest and genomic, transcriptomic and epigenomic data
  • Uses up-to-date methods to exploit omic data
  • Presents methods through specific examples and computing sessions
  • Supplemented by a website, including code, datasets, and solutions

chapter 1|20 pages

Introduction

chapter 2|25 pages

Case examples

chapter 3|20 pages

Dealing with omic data in Bioconductor

chapter 5|66 pages

Genomic variant studies

chapter 4|58 pages

Genetic association studies

chapter 6|12 pages

Addressing batch effects

chapter 7|34 pages

Transcriptomic studies

chapter 8|18 pages

Epigenomic studies

chapter 9|28 pages

Exposomic studies

chapter 10|24 pages

Enrichment analysis

chapter 11|38 pages

Multiomic data analysis