ABSTRACT
One of the most common and preferred routes of administration for the delivery of drugs is through the oral route as it is simple, convenient, and acceptable to patients, particularly in chronic therapies requiring a repeated dosage. Nanotechnology has emerged as a promising field for addressing the issues relating to drug-load capacity, toxicity, biodegradability, large dosages, and environmental considerations. In the drugs discovered, candidates possessing poor water solubility have the problems of poor and variable bioavailability associated with them. Pectin is a basic polysaccharide acquired from the cell mass of all plants, where it is ensnared in cell adhesion. More polysaccharide-based nanoparticles have been developed, which have extraordinarily improved the flexibility of nanoparticle transporters as far as structure and capacity are concerned. Nanoparticles based on polysaccharides with target-specific properties have been shown to passively target tumor tissue and effectively deliver their therapeutic payloads intracellularly through receptor-mediated endocytosis.
