ABSTRACT
256An assessment of the total antioxidant activity (AOA) of blood serum of patients with the liver disease by two chemiluminescent methods having different models of free radical oxidation: “Hb-H2O2-luminol” and “ABAP-luminol” is carried out. The comparative analysis showed not high correlation of results (r = 0.798), that is explained, mainly, by a distinction of free radical initiation mechanisms and influence of some blood serum components (proteins and bilirubins) on initiation process. More strongly it is shown in model with “Hb-H2O2.” In this regard, more preferable in clinical practice for an AOA assessment it is necessary to consider model “ABAP-luminol.” A comparison of antioxidant parameters of blood serum of patients with the affected liver with some general clinical blood characteristics, such as the content of uric acid, total and direct bilirubin, albumin, parameters of lipid metabolism is carried out.
