ABSTRACT
The development of ICSI (Intracytoplasmic sperm injection) has revolutionised the treatment of male infertility by bypassing natural barriers to fertilisation. ICSI and particularly the two sperm retrieval techniques of microsurgical epididymal sperm aspiration (MESA) and testicular sperm extraction (TESE) may cause the transmission of this or other genetic disorders to the next generation. Serious genetic diseases like cystic fibrosis and the heritability of male infertility have become important issues for discussion concerning some subpopulations of ICSI-candidates.
